The oxycodone in PERCOCET may result in spasm in the sphincter of Oddi. Opioids might lead to boosts in serum amylase. Routinely Examine individuals with biliary tract illness, such as acute pancreatitis, for worsening symptoms.Acetaminophen Gastric decontamination with activated charcoal should be administered just before N-acetylcysteine (NAC) to